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Titolo: One week terbinafine 1% cream (Lamisil (R)) once daily is effective in thetreatment of interdigital tinea pedis: a vehicle controlled study
Autore: Korting, HC; Tietz, HJ; Brautigam, M; Mayser, P; Rapatz, G; Paul, C;
- Indirizzi:
- Univ Munich, Dept Dermatol, D-80337 Munich, Germany Univ Munich Munich Germany D-80337 ept Dermatol, D-80337 Munich, Germany Humboldt Univ, Dept Dermatol, Berlin, Germany Humboldt Univ Berlin Germany boldt Univ, Dept Dermatol, Berlin, Germany Novartis Pharma GmbH, Clin Res, Nurnberg, Germany Novartis Pharma GmbH Nurnberg Germany GmbH, Clin Res, Nurnberg, Germany Univ Giessen, Dept Dermatol, Giessen, Germany Univ Giessen Giessen Germany v Giessen, Dept Dermatol, Giessen, Germany Novartis Pharma AG, Clin Res & Dev, Basel, Switzerland Novartis Pharma AGBasel Switzerland Clin Res & Dev, Basel, Switzerland
- Titolo Testata:
- MEDICAL MYCOLOGY
fascicolo: 4,
volume: 39,
anno: 2001,
pagine: 335 - 340
- SICI:
- 1369-3786(200108)39:4<335:OWT1C(>2.0.ZU;2-6
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- CLOTRIMAZOLE; INVITRO; 1-WEEK;
- Keywords:
- Lamisil (R); terbinafine; tinea pedis; topical medication;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 21
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Korting, HC Univ Munich, Dept Dermatol, Frauenlobstr 9-11, D-80337 Munich,Germany Univ Munich Frauenlobstr 9-11 Munich Germany D-80337 Germany
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- Citazione:
- H.C. Korting et al., "One week terbinafine 1% cream (Lamisil (R)) once daily is effective in thetreatment of interdigital tinea pedis: a vehicle controlled study", MED MYCOL, 39(4), 2001, pp. 335-340
Abstract
Duration of therapy is an important factor determining patients' compliance in dermatomycosis clinical practice. We undertook a prospective, randomised, double-blind, parallel group study to investigate the efficacy and tolerability of once daily treatment with terbinaftne 1% cream for q week, compared to its vehicle, in adult patients with interdigital tinea pedis. Efficacy was assessed in terms of mycological cure, total clinical signs and symptoms scores, and clinical response, 1 day and 1, 5 and 7 weeks after end of treatment. Terbinafine 1% cream was significantly more effective than itsvehicle in achieving and maintaining mycological cure for 7 weeks: 91.4% vs. 37.1%, P<0.001. Terbinafine was also significantly more effective than its vehicle in reducing total clinical signs and symptoms scores, and in achieving clinical response. We conclude that terbinafine 1% cream, applied once daily for 7 days, is an effective and well-tolerated treatment for interdigital tinea pedis in nonimmunocompromised patients. The short duration oftreatment needed to achieve mycological cure has important implications for patient compliance and for control of infection within the community.
CIB Centro Inter-Bibliotecario, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/02/10 alle ore 20:27:51